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The Tax Cuts and Jobs Act was signed into law by US President Donald Trump on 22 December 2017. Given the substantial presence of US multinational companies in Ireland, the changes to the US tax code could have significant implications for the Irish economy. In this paper, Professor Frank Barry of Trinity College Dublin outlines the history of corporate tax policy in Ireland and the US and discusses how the systems interacted up to the time of the recent changes. The likely implications of the new US tax regime for inward FDI in Ireland are also considered.